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937
Multipoint Linkage-DisequilibriumMapping Approach Based on the
Case-Parent Trio Design
Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, and Kathleen C. Barnes
951
Assessment of Parent-of-Origin Effects in Linkage Analysis of
Quantitative Traits
Robert L. Hanson, Sayuko Kobes, Robert S. Lindsay, and William C. Knowler
963
Efficient Multipoint Linkage Analysis through Reduction of Inheritance
Space
Kyriacos Markianos, Mark J. Daly, and Leonid Kruglyak
978
A New Statistical Method for Haplotype Reconstruction from Population
Data
Matthew Stephens, Nicholas J. Smith, and Peter Donnelly
457
Problems in the Definition, Interpretation, and Evaluation of Genetic
Heterogeneity
Alice S. Whittemore and Jerry Halpern
466
Accounting for Unmeasured Population Substructure in Case-Control
Studies of Genetic Association Using a Novel Latent-Class Model
Glen A. Satten, W. Dana Flanders, and Quanhe Yang
1515
Family-Based Tests of Association in the Presence of Linkage
Stephen L. Lake, Deborah Blacker, and Nan M. Laird
219
Improved Inference of Relationship for Pairs of Individuals
Michael P. Epstein, William L. Duren, and Michael Boehnke
1232
Performance of Markov ChainMonte Carlo Approaches for Mapping
Genes in Oligogenic Models with an Unknown Number of Loci
Jae K. Lee and Duncan C. Thomas
1025 A Unified Haseman-Elston Method for Testing Linkage with Quantitative Traits Xin Xu, Scott Weiss, Xiping Xu, and L. J. Wei
518
The Accuracy of Statistical Methods for Estimation of Haplotype
Frequencies: An Example from the CD4 Locus
S. A. Tishkoff, A. J. Pakstis, G. Ruano, and K. K. Kidd
523
The Problems of Using the Transmission/Disequilibrium Test to Infer Tight
Linkage
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J. C. Whittaker, M. C. Denham, and A. P. Morris
146
A Test for Linkage and Association in General Pedigrees: The Pedigree
Disequilibrium Test
Eden R. Martin, Stephanie A. Monks, Liling L. Warren, and Norman L. Kaplan
155
Bayesian Fine-Scale Mapping of Disease Loci, by Hidden Markov Models
A. P. Morris, J. C. Whittaker, and D. J. Balding
170
Association Mapping in Structured Populations
Jonathan K. Pritchard, Matthew Stephens, Noah A. Rosenberg, and
Peter Donnelly
911
Characterization of Human Crossover Interference
Karl W. Broman and James L. Weber
1933
The Power of Genomic Control
Silviu-Alin Bacanu, B. Devlin, and Kathryn Roeder
1616
Power of Linkage versus Association Analysis of Quantitative Traits, by
Use of Variance-Components Models, for Sibship Data
P. C. Sham, S. S. Cherny, S. Purcell, and J. K. Hewitt
1631
A Unified Sampling Approach for Multipoint Analysis of Qualitative and
Quantitative Traits in Sib Pairs
Kung-Yee Liang, Chiung-Yu Huang, and Terri H. Beaty
1642
Composite Statistics for QTL Mapping with Moderately Discordant Sibling
Pairs
William F. Forrest and Eleanor Feingold
1661
Power Comparison of Parametric and Nonparametric Linkage Tests in
Small Pedigrees
Pak Chung Sham, Ming-Wei Lin, Jing Hua Zhao, and David Curtis
1273
Multilocus Linkage Tests Based on Affected Relative Pairs
Heather J. Cordell, Geoffrey C. Wedig, Kevin B. Jacobs, and Robert C. Elston
1287
A Multipoint Method for Detecting Genotyping Errors and Mutations in
Sibling-Pair Linkage Data
Julie A. Douglas, Michael Boehnke, and Kenneth Lange
1298 Linkage Analysis in the Presence of Errors III: Marker Loci and Their Map as Nuisance Parameters Harald H. H. Göring and Joseph D. Terwilliger
1310
Linkage Analysis in the Presence of Errors IV: Joint Pseudomarker
Analysis of Linkage and/or Linkage Disequilibrium on a Mixture of
Pedigrees and Singletons When the Mode of Inheritance Cannot Be
Accurately Specified
Harald H. H. Göring and Joseph D. Terwilliger
1328
Detection of Disease Genes by Use of Family Data. I. Likelihood-Based
Theory
Alice S. Whittemore and I-Ping Tu
1076
Statistical Tests for Detection of Misspecified Relationships by Use of
Genome-Screen Data
Mary Sara McPeek and Lei Sun
1095
Linkage Analysis in the Presence of Errors I: Complex-Valued
Recombination Fractions and Complex Phenotypes
Harald H. H. Göring and Joseph D. Terwilliger
1107
Linkage Analysis in the Presence of Errors II: Marker-Locus Genotyping
Errors Modeled with Hypercomplex Recombination Fractions
Harald H. H. Göring and Joseph D. Terwilliger
1119
Bias and Efficiency in Family-Based Gene-Characterization Studies:
Conditional, Prospective, Retrospective, and Joint Likelihoods
Peter Kraft and Duncan C. Thomas
576
Removing the Sampling Restrictions from Family-Based Tests of
Association for a Quantitative-Trait Locus
S. A. Monks and N. L. Kaplan
593
The Relationship between the Sibling Recurrence-Risk Ratio and Genotype
Relative Risk
Benjamin A. Rybicki and Robert C. Elston
605
Family-Based Tests of Association and Linkage That Use Unaffected
Sibs, Covariates, and Interactions
Kathryn L. Lunetta, Stephen V. Faraone, Joseph Biederman, and Nan M. Laird
615
A Coalescent Approach to Study Linkage Disequilibrium between
Single-Nucleotide Polymorphisms
Sebastian Zöllner and Arndt von Haeseler
629
Estimation of Variance Components of Quantitative Traits in Inbred
Populations
Mark Abney, Mary Sara McPeek, and Carole Ober
659
Haplotype Fine Mapping by Evolutionary Trees
Johnny C. Lam, Kathryn Roeder, and B. Devlin