Biostat 580B - Statistical Genetics Seminar

Instructor: Ellen Wijsman
Instructor: Elizabeth Thompson

Yes, I do know all these style files and gif's don't work, but if I fix them, then I'll have to fix them back again, when this file goes back to Biostat.

1 credit

Spring Quarter 2001
Seminar: Tuesday 4:00-5:00 in Biostat Conference Room

Reminder: Everyone should read the papers (make a copy from the copy left in the stat mailbox, or the purple biostat 580B homework folder under the biostat mailboxes). Discussion leaders are only expected to spend 15-20 minutes presenting the assigned papers. If you don't understand everything, focus on what you can, and try to think about what is important about the papers, and what open questions you are left with.

Remember the important questions:

Why? What? Why? How? Why? What next? and WHY?

SEE BELOW for Announcements

Spring Schedule

• March 27: Organizational meeting: Please look at this list of possible papers.

  Focusing on recent journal papers, we decided to address various issues in the analysis of complex traits. We will start with variance component methods (weeks 2,3,5) and then talk also about genetic vs physical distance (week 4), allele sharing methods (week 6?), gamete competion and maternal effects models (week 8?), and disequilibrium (week 9). Andrew and Stephanie will fill out the quarter.

• April 3: Amy Anderson and Lindsey Dubb
  Blangero, Williams, Almasy, (2001)
  Variance component methods for detecting complex trait loci
  Adv Genet 42: 151-181.

• April 10: Michael Li and Mike Badzioch
  The same continued

• April 17: Nicky Chapman and Paul Scheet
  Comparison of human genetic and sequence-based physical maps
  Yu et al., Nature 409:951-953 February 15, 2001.
  
  The DNA sequence of human chromosome 21
  Hattori et al., Nature 405:311-319 May 18 2000.

• April 24: Elisabeth Rosenthal and Mary Kuhner
  Estimation of Variance Components of Quantitative Traits in Inbred Populations
  Mark Abney, Mary Sara McPeek, and Carole Ober
  AJHG, Feb 2000, P. 629--

• May 1: Bill Stewart and Saonli Basu
  

  Dudoit and Speed: (2000)
  A score test for linkage analysis of qualitative and quantitative traits based on identity by descent on sib pairs.
  Biostatistics 1: 1-26

• May 8: Andrew George
  MCMC for novices.

• May 15: Jackie Starr amd Solly Sieberts
  Sinsheimer, Blangero, and Lange (2000).
  Gamete competition models.
  Am. J. Hum Genet. 66: 1168-1172.

• May 22: Elizabeth Thompson and Hao Liu
  (Unfortunately we will not be able to coordinate our presentations ahead of time, as Elizabeth will not be here-- so this is an unavoidable exception -- not the way others should do it!)
  Elizabeth will give some background about TDT and the relationship between so-called association testing and other forms of linkage analysis.
  Hao will present
  Multipoint Linkage-Disequilibrium Mapping Approach Based on the Case-Parent Trio Design
  Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, and Kathleen C. Barnes
  Am. J. Hum Genet. 68 (4) 937--351.
  

• May 29: Stephanie Monks Will relate expression data to more familiar topics in study of related individuals (maybe).

Announcements

Andrew Strahs from Chicago will be visiting to check out UW April 19-20. He will give the informal seminar in the Friday group meeting (2.30 in C301). Here are the title and abstract. Statgen people are welcome.

CONGRATULATIONS to Heike Bickeboller
Heike Bickeb"oller (Statistics Ph.D., 1993) has been appointed to a full C3 Professorship at University of G"ottingen, Germany, as head of a new Department of Genetic Epidemiology there.